Lewis & Clark College of Arts & Sciences

Undergraduate Catalog

Biochemistry and Molecular Biology

Director: Greg J. Hermann
Administrative Assistant: Amy Timmins

The molecular logic of living organisms is the focus of this major. Biochemists and molecular biologists study how the collection of molecules within the cell interact to maintain and perpetuate life. The biochemistry/molecular biology major at Lewis & Clark provides students with an opportunity to pursue an interdisciplinary course of study that follows the guidelines of the American Society for Biochemistry and Molecular Biology. Students majoring in biochemistry/molecular biology devote their first years of study to mastering the basic tenets of calculus, physics, genetics, and chemistry. Upper-division coursework exposes students to current research in biochemistry and cellular and molecular biology.

The distinctive character of our program derives from the curricular goals that shape it. Faculty associated with the biochemistry/molecular biology program are proponents of a lab-rich, investigative education for undergraduates in the sciences. Opportunities for scientific inquiry are woven into the laboratory curriculum and prepare the student ultimately to undertake collaborative research projects with the faculty. To foster the ability of our students to engage independently in the scientific process, we devote class time to critically reading the primary literature. In our laboratory courses, students participate in selecting and designing their experiments. The curriculum is constructed to engage students in the scientific process and thereby facilitate the development of reflective judgment and problem-solving skills.

Students majoring in biochemistry/molecular biology are guided by sponsoring faculty from both the biology and chemistry departments. The major prepares students for careers in biomedical research, biotechnology, and genetic engineering. It is especially suitable for students seeking admission to medical or dental schools, or to graduate programs in biochemistry, cell or molecular biology, or genetics. Students majoring in biochemistry/molecular biology may not minor in biology or chemistry.

Major Requirements

A minimum of 54 semester credits in biology and chemistry (11 semester credits of which are granted for associated laboratory work), plus courses in mathematics and physics, distributed as follows:

Honors

Biochemistry/molecular biology majors who have distinguished themselves academically by earning a GPA of 3.500 or higher in the major and overall, have completed either BIO 312 or CHEM 336, and have some prior research experience are invited in the spring of their junior year to participate in the senior thesis program. Students who accept the invitation work with a faculty advisor to develop a research project, which must be approved by faculty overseeing the biochemistry/molecular biology major. Following the experimental work, students prepare a written thesis and orally defend it during the spring semester of the senior year. Honors are awarded to those students whose thesis is judged to be meritorious.

Faculty

Greta J. Binford. Associate professor of biology. Invertebrate zoology, biodiversity, evolution of spider venoms. Ph.D. 2000 University of Arizona. M.S. 1993 University of Utah. B.A. 1990 Miami University.

Greg J. Hermann. Associate professor of biology, director of the Biochemistry and Molecular Biology Program. Developmental genetics and cell biology. Ph.D. 1998 University of Utah. B.S. 1992 Gonzaga University.

Janis E. Lochner. Dr. Robert B. Pamplin Jr. Professor of Science. Biochemistry. Ph.D. 1981 Oregon Health Sciences University. B.S. 1976 Allegheny College.

Nikolaus M. Loening. Associate professor of chemistry, fall 2011 chair of the Department of Chemistry. Physical chemistry, biophysical chemistry. Ph.D. 2001, M.Phil. 1998 University of Cambridge. B.S. 1997 Harvey Mudd College.

Deborah E. Lycan. Professor of biology. Molecular biology, cell biology, ribosome biogenesis in eukaryotic cells, yeast genetics. Ph.D. 1983 University of Colorado. B.A. 1975 University of California at San Diego.

C. Gary Reiness. Professor of biology. Cell biology, neurobiology, development of the vertebrate nervous system. Ph.D. 1975, M.Phil. 1974 Columbia University. B.A. 1967 Johns Hopkins University.

Bethe A. Scalettar. Professor of physics. Fluorescence microscopy, biophysics, optics, thermodynamics, quantum mechanics. Ph.D. 1987 University of California at Berkeley. B.S. 1981 University of California at Irvine.

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BCMB 410 Biochemistry/Molecular Biology Seminar

Faculty: Biochemistry and Molecular Biology Faculty.
Content: Select topics in biochemistry and molecular biology. Students attend seminars of invited outside researchers and prepare an oral seminar on their own research or on a critical analysis of a relevant research publication.
Prerequisites: BIO 311. CHEM 330. CHEM 335 (may be taken concurrently).
Restrictions: Sophomore standing required.
Usually offered: Annually.
Semester credits: 1.

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BCMB 496 Biochemistry/Molecular Biology Senior Research

Faculty: Biochemistry and Molecular Biology Faculty.
Content: In-depth laboratory inquiry into a question relevant to biochemistry/ molecular biology. Students develop a thesis proposal in association with a faculty mentor, conduct extensive experimental work to address their hypothesis, and present their analysis of their findings in a written thesis. 4 credits each semester of the senior year.
Prerequisites: None.
Restrictions: By invitation only. Senior standing required.
Usually offered: Annually, fall and spring semester.
Semester credits: 4.

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BCMB 499 Independent Study

Faculty: Biochemistry and Molecular Biology Faculty.
Content: Participation in a faculty-supervised research project at Lewis & Clark or another research institution. Further information available from biochemistry program faculty members. May be repeated for credit.
Prerequisites: None.
Restrictions: Approval of project proposal by program and supervising faculty member and sophomore standing required.
Usually offered: Annually, fall and spring semester.
Semester credits: 2-4.